Design And Characterization Of Latanoprost In situ Gel.
Keywords:
In Situ Gel Opthalmic System, Bioavailability, Enhanced Residential Time, ViscosityAbstract
In recent years, the In Situ gelling system has emerged as a promising drug delivery system in the ophthalmic domain. The current study focuses on the development and evaluation of an in-situ gelling system for treating glaucoma by increasing ocular residence time and bioavailability. Temperature sensitive polymers such as Pluronic F-127 and viscosifying agents such as HPMC K4M in various concentrations were used to create in situ gelling formulations.
References
Ahmed VA, Goli D. Xyloglucan based in situ gel: Formulation Development and evaluation of in situ ophthalmic gel of Brimonidine tartarate. Indo Global J Pharm Sci, 2018;8(3):92-103.
Available at: https://www.ema.europa.eu/en/human-regulatory/research-development/scientific-guidelines/quality/quality-stability
Available at: https://www.fda.gov/regulatory-information/search-fda-guidance documents/q1ar2-stability-testing-new-drug- substances-and-products
