The Pediatric Burden of Primary Immune Deficiencies: A Quality of Life Perspective

Abstract

Background: Primary immune deficiency diseases (PIDDs) represent a diverse group of over 450 genetic disorders that compromise the immune system’s function, leading to heightened susceptibility to infections, autoimmunity, and malignancy. In pediatric populations, these chronic conditions significantly disrupt physical health, emotional well-being, and social integration, resulting in a markedly reduced health-related quality of life (HRQoL). This review explores the multidimensional burden of PIDD on affected children and their families, emphasizing both clinical and psychosocial domains. Frequent infections and medical interventions often result in prolonged school absences, impaired academic performance, and limited social engagement.