Innovative Targets in Deep Brain Stimulation: Advancing Neurosurgical Treatment of Movement Disorders

Authors

  • Samy Hassanen Mohamed, Magdy El-Sayed Hassan Rashed , Amr Mohamed Mohamed El Bakry, Ahmed El-Shabrawy Sweilam

Keywords:

Deep Brain Stimulation, Targets, Neurosurgical Treatment , Movement Disorders

Abstract

Background: Deep brain stimulation (DBS) has revolutionized the management of movement disorders such as Parkinson's disease, essential tremor, and dystonia by targeting well-established structures like the subthalamic nucleus (STN), globus pallidus internus (GPi), and ventral intermediate nucleus (VIM) of the thalamus. Despite the substantial symptomatic relief these conventional targets offer, limitations related to adverse effects and incomplete symptom control have prompted the exploration of novel DBS targets aimed at improving therapeutic outcomes.

References

Lozano AM, Lipsman N. Probing and regulating dysfunctional circuits using deep brain stimulation. Neuron. 2013;77(3):406-424.

Plaha P, Ben-Shlomo Y, Patel NK, Gill SS. Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism. Brain. 2006;129(7):1732-1747.

Blomstedt P, Sandvik U, Tisch S. Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor. Mov Disord. 2010;25(10):1350-1356.

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Published

2024-06-11

How to Cite

Samy Hassanen Mohamed, Magdy El-Sayed Hassan Rashed , Amr Mohamed Mohamed El Bakry, Ahmed El-Shabrawy Sweilam. (2024). Innovative Targets in Deep Brain Stimulation: Advancing Neurosurgical Treatment of Movement Disorders . Journal of Computational Analysis and Applications (JoCAAA), 33(06), 1560–1566. Retrieved from https://www.eudoxuspress.com/index.php/pub/article/view/2210

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Articles